investigation of the role of placenta in transfer of bromine containing drugs to infants

a study was undertaken to investigate the role of placenta in transferring drugs containing bromine to the infant. 20 pregnant subjects were given bromine as kbr (500 mg/50 kg weight) 10h before the delivery the bromine content of the serum in the mother and the child was estimated by neutron.. 13 lrradlated at 2xlo activation analysis. samples were -2 -1 n em 5 for a period of one hour. a ge (li) detector connected to an 800 channel analyser 82 was used for measuring br photopeaks. in 72% of the cases the distribution of bromine in both mother and child was equal, revealing a transfer across the placenta of the intaken drug.